Method Development and Validation of Lorazepam by Using RP-HPLC in Pharmaceutical Formulation

Authors

  • J.R.V.Prasanna
  • D.Narendra
  • K.Susritha Reddy
  • A.Lakshmi Tulasi
  • A.Nikhitha
  • M.Krishna Sowmya Sri VJ’s College of Pharmacy, Diwancheruvu, Rajamahendravaram, Andhra Pradesh, India.

DOI:

https://doi.org/10.47070/ijraps.v7i4.139

Abstract

High pressure liquid chromatography (RP-HPLC) is a column chromatographic technique employing high pressure pump to pass both mobile phase and sample mixture through stationary phase column and perform efficient separation. A C-18 column with mobile phase containing Acetonitrile: methanol (80: 20) was used. The flow rate was 1.0ml/min. and were monitored at 210 nm. The retention time for Lorazepam was 1.3 min. The method was validated for linearity, accuracy, precision, limit of detection. The Mean percent recovery of Lorazepam from tablet formulation was found to be 94.80 %.

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Published

2023-04-22

Issue

Vol 7, Issue 4: April 2023

Section

Articles

How to Cite

1.
Method Development and Validation of Lorazepam by Using RP-HPLC in Pharmaceutical Formulation. IJRAPS [Internet]. 2023 Apr. 22 [cited 2026 Jul. 14];7(4):1-3. Available from: https://ijraps.in/index.php/ijraps/article/view/139

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