Clinical Evaluation of an Herbal-Probiotic Nutraceutical Supplement in Improving Symptoms of Yakrut Vikaara, Kaamala, and Pleeha Roha: A Pilot Clinical Study

Abstract

The liver, as the body’s primary detoxification organ, is highly vulnerable to toxins such as heavy metals, pesticides, industrial chemicals, and alcohol. These substances can cause oxidative stress, inflammation, and liver cell damage, potentially leading to fatty liver disease like the development of non-alcoholic fatty liver disease (NAFLD), cirrhosis, or liver cancer. Environmental pollutants from air and water further contribute to liver dysfunction by overwhelming detoxification pathways and promoting chronic metabolic disturbances. Herbal and probiotic-based nutraceuticals have shown promise in supporting detoxification and improving digestive health. This pilot study evaluated the safety and efficacy of a novel nutraceutical supplement formulated with six herbs and a probiotic in patients with liver disorders, hepatitis, and spleen-related disorders exceeding 30% of the population in Salem city, India. Methods: In a Phase I, single-centre, open-label clinical trial, 10 patients (40% female, 60% male) diagnosed with liver and spleen disorders presenting symptoms including excessive tiredness, shortness of breath, loss of appetite, nausea, abdominal pain, fatigue, and bloating were administered the supplement. Symptom improvement was assessed over the study period. Results: The nutraceutical demonstrated a high level of tolerability among participants, with no significant adverse effects reported. Notably, 80% of the patients experienced noticeable improvements across a broad range of symptoms. These positive outcomes suggest that the product may offer beneficial effects in several key areas, including the body’s natural detoxification processes, digestive function, and the maintenance of overall health and well-being. These findings highlight the potential of the nutraceutical as a supportive supplement for individuals seeking to enhance their physiological balance and general vitality. Conclusion: This pilot study suggests that the six-herb probiotic nutraceutical supplement may offer symptomatic relief and support detoxification in patients with liver and spleen disorders. Larger, controlled studies are warranted to confirm these findings.